Áhættuþættir sóragigtar - verkefni lokið

Fréttatilkynning verkefnisstjóra


Psoriatic arthritis is an inflammatory joint disease which can cause significant disability. It primarily occurs among individuals who already have developed the skin disease psoriasis. This project is part of an international collaboration involving the University of Iceland, Boston University, the University of Pennsylvania, and Harvard Medical School, and the Icelandic Research Fund funded the participation of an Icelandic researcher and his master‘s students in the project.

Heiti verkefnis: Áhættuþættir sóragigtar
Þorvarður Jón Löve, Landspítala - háskólasjúkrahúsi
Tegund styrks: Verkefnisstyrkur
Styrkár: 2012-2014
Fjárhæð styrks: 14,738 millj. kr. alls
Tilvísunarnúmer Rannís:  120433

The project funded by IRF was led by an Icelandic investigator and was aimed at understanding risk factors for psoriatic arthritis so that we can better understand who is most likely to develop arthritis among psoriasis patients, with the goal of one day being able to advise patients with psoriasis on their risk for arthritis, and perhaps modify it.

Results: Two new risk factors for psoriatic arthritis have been established by this project: obesity and trauma. Furthermore, smoking has been found to increase the risk for psoriatic arthritis through an increased risk of developing psoriasis, but does not seem to change the risk for arthritis after psoriasis has developed.

Impact: These results give insights into potential mechanisms for the development of arthritis among patients with psoriasis, as well as paving the way for developing a risk assessment score and potentially risk modification strategies in the future.

Project outputs: One paper has been published and three are in manuscript from the Icelandic portion of this project with a focus on risk factors, but the collaboration has resulted in several other publications. In addition to these, the findings on obesity and psoriatic arthritis were an Editor‘s Choice in the Annals of Rheumatic Diseases, the highest impact journal on arthritis, and the results on trauma have received significant media attention including interviews with the Icelandic project leader, such as the one in this link: http://www.medpagetoday.com/MeetingCoverage/EULAR/52072. Findings from this project have been selected for oral presentations at both the EULAR and ACR conferences, the largest conferences on rheumatology in Europe and the United states, each with an annual attendance of approximately 16,000.

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