Defining the metabolic alterations that underlie the epithelial to mesenchymal transition - verkefni lokið
Fréttatilkynning verkefnisstjóra
We, researchers at the Center for System Biology in the University of Iceland, have built a computational model to understand the metabolism of breast epithelium. The model aims to understand the metabolic alteration during epithelial to mesenchymal transition (EMT) which is an important event during development and cancer metastasis.
Epidermal growth factor receptor (EGFR) pathway is one such signaling pathway that controls/regulates growth, survival, proliferation and induction of EMT in the mammalian cells.
We therefore, aimed at the EGFR signaling cascade to investigate the crosstalk between signaling cascade and metabolic alterations during EMT in breast epithelial cell lines. The computational model was further used to obtain signaling and metabolic biomarkers of EMT.
These signaling and metabolic biomarkers may help in understanding the molecular mechanisms that underlie EMT and cancer metastasis. The results highlights how the metabolic biomarkers of cancer cell growth and EMT can be predicted based on the transcriptome analysis of EGFR signaling genes alone. The result also highlights that the signal regulation during EMT could be cell line or EMT inducer specific which means drugs against EMT or cancer metastatsis has to be carefully monitored and cannot be designed based on single cell line study.
Heiti verkefnis: Defining the
metabolic alterations that underlie the epithelial to mesenchymal transition
Verkefnisstjóri: Kumari Sonal Ranjit Choudhary
Tegund styrks: Rannsóknastöðustyrkur
Styrktímabil: 2015-2016
Fjárhæð styrks: 14,78 millj. kr. alls
Tilvísunarnúmer Rannís: 152369
